General Supervisor, Oncology

Menlo Park, CA

Ready to redefine what's possible in molecular diagnostics?

Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today. Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments. If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong. BillionToOne is seeking a Clinical Laboratory General Supervisor (GS) to support our Oncology product, Northstar, in a high-complexity CLIA laboratory environment. This role provides general supervision of personnel and daily laboratory operations, ensuring regulatory compliance, quality, and operational excellence across end-to-end cancer blood sample processing. This is a hands-on leadership role in a fast-growing, high-throughput molecular diagnostics lab. The General Supervisor will serve as a key operational leader and first point of escalation for CLS and CLA, partnering closely with theTechnical Supervisor, Laboratory Director, and Quality team. This is an onsite position supporting the MondayFriday Mid Shift (11:30 AM 8:00 PM), with a planned transition to a PM shift (3:00 PM 11:30 PM) later this year.

Responsibilities:

General Supervision & Leadership
Serve as adesignated CLIA General Supervisor for high-complexity testing in accordance with 42 CFR Part 493 and CAP accreditation standards
Provideday-to-day supervision of laboratory personnel, including CLSs and CLAs, during the pre-analytic, analytic, and post-analytic phases of testing
Act as theprimary escalation point for technical, operational, and personnel issues during assigned shifts
Oversee staffing, scheduling, shift handoffs, and workload distribution to ensure operational continuity
Laboratory Operations & Testing
Perform and overseehigh-complexity molecular oncology assays, supporting diagnostic testing for patient care
Ensure properinstrument operation, calibration, maintenance, and troubleshooting
Review, interpret, and verify test results and quality control data
Identify, investigate ,and resolve deviations that may impact test performance or result integrity
Quality & Compliance
Ensure compliance withCLIA ,CAP ,state ,and local regulatory requirements
Perform ,review ,and documentquality control ,corrective actions ,and preventive maintenance
Participate ininspection readiness ,audits ,and regulatory responses
Lead or support SOP development ,review ,and biennial updates
Training & Continuous Improvement
Lead training ,onboarding ,and competency assessments for new and existing laboratory staff
Provide hands-on and theoretical training for new assays ,processes ,and instrumentation
Supportprocess improvement initiatives ,including assay validation ,tech transfer ,and troubleshooting
Partner cross-functionally with Quality ,R&D ,and Operations to drive continuous improvement

Qualifications:

Active California Clinical Laboratory Scientist (CLS) license (or CGMBS/generalist license) meeting CLIA requirements for high-complexity testing
Bachelor’s degree in chemical ,biological ,physical ,clinical laboratory science or related field
Minimum 4 years of clinical laboratory experience including molecular/high-complexity testing
MeetsCLIA General Supervisor qualifications under 42 CFR 493.1461 including appropriate education/training/experience
Demonstrated hands-on experience with molecular biology techniques (e.g., DNA extraction PCR automated liquid handlers)
Strong working knowledge of LIMS quality systems laboratory documentation
Proficiency with Google Docs Excel Word basic statistical analysis
Excellent attention to detail organizational skills ability to perform under time-sensitive conditions
Strong written verbal communication skills collaborative leadership style

Nice-To-Haves:

Prior experience serving as a CLIA General Supervisor
Startup or high-growth laboratory experience
Background in medical genetics or oncology diagnostics
Experience working with cell-free DNA (cfDNA) or next-generation sequencing workflows

Benefits And Perks:

Working alongside brilliant kind passionate dedicated colleagues in an empowering environment toward a global vision striving for transformative molecular diagnostics helping millions of patients
Open transparent culture including weekly Town Hall meetings
Ability to indirectly or directly change lives of hundreds of thousands patients
Multiple medical benefit options; employee premiums paid 100% select plans dependents covered up to 80%
Extremely generous Family Bonding Leave for new parents (16 weeks paid at 100%)
Supplemental fertility benefits coverage
Retirement savings program including a 4% Company match
Increased paid time off with increased tenure
Latest hardware (laptop lab equipment facilities)
Daily on-site lunches from top eateries
Variety of perks on campus (state-of-the-art gym restaurant)
Free on-site EV charging (compatible with all EVs including Tesla)

At BillionToOne we offer combination of:

Base pay range (actual amount based on experience salary/equity options split candidate chooses)

Generous equity options offering Corporate bonus program Industry leading company benefits (free healthcare options 401k match fully paid parental leave etc.)

total compensation package: $217805 per year including base pay range $158401 - $179521 per year. BillionToOne is an equal opportunity employer. We do not discriminate on basis of race religion color national origin gender sexual orientation age marital status veteran status disability status. fOr more information about how we protect your information please review our Privacy Policy. and so forth...