Head of Engineering

Location

San Francisco

Employment Type

Full time

Department

Engineering

Compensation

• $200K – $250K • Offers Equity

About Probably Genetic

Probably Genetic is changing the lives of patients living with severe, complex diseases. Our data platform is used by drug developers and patient advocacy groups to develop and launch treatments for these patients. Our technology discovers undiagnosed patients online, analyzes their disease state using machine learning and at-home testing, and enables compliant communication with patients. In doing so, we help patients access diagnoses, clinical trials, and treatments as early as possible. We are a tight-knit group of hard-working, ambitious problem solvers united by a mission greater than ourselves. We do well by doing right by patients. We are developing some of the most cutting-edge solutions in healthcare, and our roadmap is packed with innovations in bioinformatics, AI, and drug development. We have built a lean, all-star team to help us bring our vision to life, and we want you to be a part of it. Probably Genetic has raised multiple rounds of funding from Silicon Valley’s best investors, including Threshold, Khosla, and Y Combinator, and offer competitive salaries, comprehensive benefits, and meaningful early stage equity.

About the role

We’re looking for a visionary builder–leader to serve as our next Head of Engineering. This is a rare opportunity for an experienced engineering leader who still loves to code — someone excited to roll up their sleeves, ship critical systems themselves, and lay the technical foundations for something remarkable. In the near term, you’ll be deeply hands-on: architecting and writing production code, shaping our AI and software systems, and partnering closely with Product to turn strategy into shipped features. Over time, you’ll scale the team and evolve from player–coach to executive leader, owning the technical vision that powers the future of precision medicine through AI.

What you will do

Technical Leadership (Player–Coach First)

• Personally design,... ship core components of our AI platform,...
• Set coding standards... establishing a high bar...
• Partner with Head of Product,... executive team...
• Ensure security,... scalability,... reliability...

Team & Culture

• Lead as player–coach: contribute code while mentoring engineers.
• Recruit & grow high-performing team.
• Build culture of ownership & excellence.
• Collaborate closely with Product,...

Execution & Delivery

• Drive high-quality execution balancing speed & rigor.
• Establish pragmatic engineering processes.
• Oversee infrastructure decisions & budgets.

Strategic Partnership

• Work closely with CEO & exec team on strategy.
• Represent technology externally.
• Support fundraising & due diligence.

Who you are

We’re looking for a technical leader comfortable in codebase & boardroom:

• Served as CTO/VP/Head or senior leader in startups or high-growth tech companies (healthtech/AI preferred).
• Excited to be hands-on again; architect systems & ship code.
• Built/scaled teams through 0→1 & 1→n phases.
• Fluent in Python/Django (backend), React/Typescript (frontend), AWS (infra), Terraform (ETL).
• Experienced building in regulated environments (HIPAA,SOC2,etc).
• Systems thinker moving between architecture & strategy.
• Motivated by mission to improve patient lives.

Not required but helpful:

• Experience in AI diagnostics,... genomics or precision medicine.
• Background in bioinformatics or health data systems.
• Exposure to biopharma companies/labs.

As all hires:

• Good person; empathy key working with marginalized populations.
• Patient-focused; motivated for lasting impact.
• Comfortable in fast-paced ambiguous environment.
• Action-oriented; excited to build company ground up.

What we offer:

• Engaging supportive team on mission to improve lives.
• Fair compensation + early-stage equity grants.
• Generous flexible time off policy used genuinely.
• Parental leave benefits (12 weeks birthing/non-birthing).
• Hybrid flexible work; high trust/autonomy.
• Bright pet-friendly office Downtown SF near transit.
• Work from anywhere policy up to 4 weeks/year.
• Regular team retreats in exciting destinations.
• Health benefits: medical/dental/vision/therapy/FSA/401k etc.
• And more!

Probably Genetic committed fostering welcoming inclusive environment for all genders/sexualities/ethnicities/backgrounds/life experiences; encourages candidates of all backgrounds; accommodations available on request during interview/work consideration process.